Systematic reviews of health effects of social interventions: 1. Finding the evidence: how far should you go?

Study objective: There is little guidance on how to identify useful evidence about the health effects of social interventions. The aim of this study was to assess the value of different ways of finding this type of information. Design: Retrospective analysis of the sources of studies for one systematic review. Setting: Case study of a systematic review of the effectiveness of interventions in promoting a population shift from using cars towards walking and cycling. Main results: Only four of the 69 relevant studies were found in a "first-line" health database such as Medline. About half of all relevant studies were found through the specialist Transport database. Nine relevant studies were found through purposive internet searches and seven relevant studies were found by chance. The unique contribution of experts was not to identify additional studies, but to provide more information about those already found in the literature. Conclusions: Most of the evidence needed for this review was not found in studies indexed in familiar literature databases. Applying a sensitive search strategy across multiple databases and interfaces is very labour intensive. Retrospective analysis suggests that a more efficient method might have been to search a few key resources, then to ask authors and experts directly for the most robust reports of studies identified. However, internet publications and serendipitous discoveries did make a significant contribution to the total set of relevant evidence. Undertaking a comprehensive search may provide unique evidence and insights that would not be obtained using a more focused search

Promoting walking and cycling as an alternative to using cars: systematic review

Objectives: To assess what interventions are effective in promoting a population shift from using cars towards walking and cycling, and to assess the health and distributional effects of such interventions. Data sources: Published and unpublished reports in any language identified from electronic databases, bibliographies, websites and reference lists. Review methods: Systematic search and appraisal to identify experimental or observational studies with a prospective or controlled retrospective design that evaluated any intervention applied to an urban population or area by measuring outcomes in members of the local population. Results: 22 studies met the inclusion criteria. We found some evidence that targeted behaviour change programmes can change the behaviour of motivated subgroups, resulting (in the largest study) in a modal shift of around 5% of all trips at a population level. Single studies of commuter subsidies and a new railwy station have also shown modest effects. The balance of best available evidence about publicity campaigns, engineering measures and other interventions suggests that they have not been effective. Participants in trials of active commuting experienced short-term improvements in certain health and fitness measures, but we found no good evidence about the health effects of any effective population-level intervention. Conclusions: The best available evidence of effectiveness is for targeted behaviour change programmes, but the social distribution of their effects is unclear and some other types of intervention remain to be rigorously evaluated. We need a stronger evidence base for the health impacts of transport policies, preferably based on properly conducted prospective studies

Spiral Growth Manufacturing (SGM) – A Continuous Additive Manufacturing Technology for Processing Metal Powder by Selective Laser Melting

Spiral growth manufacturing is a new innovative powder based rapid manufacturing technique. The innovation exists in the methodology in which powder layers are deposited. Unlike other pre-placed powder systems, the deposited layers move relative to the location at which they are processed. This is made possible by a rotating build drum into which powder is deposited, in spiralled layers, from a stationary hopper. With this configuration powder can be continuously deposited and levelled and simultaneously processed, eliminating delays in the build cycle. Stainless steel and cobalt-chrome powder is selectively melted using a 100W flash lamp pumped Nd:YAG laser. This paper reports on factors affecting build rate and on build strategies for creating a number of axis-symmetric thin and thick walled cylinders. Experimental results suggest that build rate for thin walled structures bonded to a substrate will ultimately be governed by tangential movements of the powder particles when frictional forces are not sufficient to accelerate the particles along a curved path, provided that enough laser power is available for melting. Even melt pool balling, which is evident when melting one layer at high speeds, diminishes in multiple layer builds due to re-melting and infilling.Mechanical Engineerin

Image Transformations and Printing of Plaster Layers in Spiral Growth Manufacturing

Spiral growth manufacturing (SGM) is a high speed rapid manufacturing technique in which objects are built up, layer by layer, by simultaneously depositing, levelling and selectively consolidating thin powder layers onto a rotating build platform. The size and position of the jetted droplets are mapped by the position and greyscale level of pixels within an 8 bit greyscale bitmap image. This paper reports on the development of software in which mathematical algorithms apply geometric transformations to images in preparation for printing onto a rotating substrate. In support of this work, dimensional accuracy measurements of printed images and methods to correct radial print density variations are reported. The accuracy of printed images were found to be within ±0.2mm of their predicted size. The experimental work is briefly extended to the direct printing of plaster layers, formed by mixing two reactive ink solutions.Mechanical Engineerin

Acoustic emission spectral analysis of fiber composite failure mechanisms

The acoustic emission of graphite fiber polyimide composite failure mechanisms was investigated with emphasis on frequency spectrum analysis. Although visual examination of spectral densities could not distinguish among fracture sources, a paired-sample t statistical analysis of mean normalized spectral densities did provide quantitative discrimination among acoustic emissions from 10 deg, 90 deg, and plus or minus 45 deg, plus or minus 45 deg sub s specimens. Comparable discrimination was not obtained for 0 deg specimens

Prawn Shell Chitosan Has Anti-Obesogenic Properties, Influencing Both Nutrient Digestibility and Microbial Populations in a Pig Model

This study was supported financially (Grant-Aid Agreement No. MFFRI/07/01) under the Sea Change Strategy with the support of the Marine Institute and the Department of Agriculture, Food and the Marine, funded under the National Development Plan 2007–2013.peer-reviewedThe potential of natural products to prevent obesity have been investigated, with evidence to suggest that chitosan has anti-obesity effects. The current experiment investigated the anti-obesity potential of prawn shell derived chitosan on a range of variables relevant to obesity in a pig model. The two dietary treatment groups included in this 63 day study were: T1) basal diet and T2) basal diet plus 1000 ppm chitosan (n = 20 gilts per group (70 ± 0.90 kg). The parameter categories which were assessed included: performance, nutrient digestibility, serum leptin concentrations, nutrient transporter and digestive enzyme gene expression and gut microbial populations. Pigs offered chitosan had reduced feed intake and final body weight (P< 0.001), lower ileal digestibility of dry matter (DM), gross energy (GE) (P< 0.05) and reduced coefficient of apparent total tract digestibility (CATTD) of gross energy and nitrogen (P<0.05) when compared to the basal group. Fatty acid binding protein 2 (FABP2) gene expression was down-regulated in pigs offered chitosan (P = 0.05) relative to the basal diet. Serum leptin concentrations increased (P< 0.05) in animals offered the chitosan diet compared to pigs offered the basal diet. Fatness traits, back-fat depth (mm), fat content (kg), were significantly reduced while lean meat (%) was increased (P<0.05) in chitosan supplemented pigs. Pigs offered chitosan had decreased numbers of Firmicutes in the colon (P <0.05), and Lactobacillus spp. in both the caecum (P <0.05) and colon (P <0.001). Bifidobacteria populations were increased in the caecum of animals offered the chitosan diet (P <0.05). In conclusion, these findings suggest that prawn shell chitosan has potent anti-obesity/body weight control effects which are mediated through multiple biological systems in vivo.This study was supported financially (Grant-Aid Agreement No. MFFRI/07/01) under the Sea Change Strategy with the support of the Marine Institute and the Department of Agriculture, Food and the Marine, funded under the National Development Plan 2007–2013

Smoking and intention to quit in deprived areas of Glasgow: is it related to housing improvements and neighbourhood regeneration because of improved mental health?

Background: People living in areas of multiple deprivation are more likely to smoke and less likely to quit smoking. This study examines the effect on smoking and intention to quit smoking for those who have experienced housing improvements (HI) in deprived areas of Glasgow, UK, and investigates whether such effects can be explained by improved mental health. Methods: Quasi-experimental, 2-year longitudinal study, comparing residents’ smoking and intention to quit smoking for HI group (n=545) with non-HI group (n=517), adjusting for baseline (2006) sociodemographic factors and smoking status. SF-12 mental health scores were used to assess mental health, along with self-reported experience of, and General Practitioner (GP) consultations for, anxiety and depression in the last 12 months. Results: There was no relationship between smoking and HI, adjusting for baseline rates (OR=0.97, 95% CI 0.57 to 1.67, p=0.918). We found an association between intention to quit and HI, which remained significant after adjusting for sociodemographics and previous intention to quit (OR 2.16, 95% CI 1.12 to 4.16, p=0.022). We found no consistent evidence that this association was attenuated by improvement in our three mental health measures. Conclusions: Providing residents in disadvantaged areas with better housing may prompt them to consider quitting smoking. However, few people actually quit, indicating that residential improvements or changes to the physical environment may not be sufficient drivers of personal behavioural change. It would make sense to link health services to housing regeneration projects to support changes in health behaviours at a time when environmental change appears to make behavioural change more likely

Open Futures: an enquiry- and skills- based educational programme developed for primary education and its use in tertiary education

Open Futures is a transforming enquiry-based and skills-based system for education that is central to the curriculum, linking learning and life. It was developed to help children discover and develop practical skills, personal interests and values, which will contribute to their education and help to enhance their adult lives. Open Futures works in partnership with groups of schools in local clusters to develop a bespoke training programme, which extends the existing curriculum and nurtures independent learning through pupil-led approaches to personal learning. Schools benefit from the experience, knowledge and support of like-minded education professionals locally, nationally and internationally. Working with schools and their communities in the UK and India, Open Futures has been running with widespread success for 9 years. It now reaches more than 30,000 children in the UK. There is a body of independent evidence from primary and secondary education showing that both individual strands, as well as the complete Open Futures programme, significantly improve learner outcomes. We now wished to move Open Futures into the tertiary education sector. It was felt that an Open Futures approach to learning and teaching, particularly involving askit, would be beneficial to the community of learners at Central Bedfordshire Further Education College, rated Grade 2 by Ofsted in October 2013. Training has been in three areas so far: Construction, Public Services and Pathways (i.e. Learners with learning difficulties and disabilities). In all cases, there were significant positive impacts for learners and for teachers. As experience with Open Futures develops in the College, it should become clear how such a central enquiry-based and skills-based approach will help learners, and provide evidence for the use of Open Futures in tertiary education that could be used in other tertiary educational institutions

The Plains of Mars, European War Prints, 1500-1825

Over fifty original prints by renowned artists from the sixteenth through the early nineteenth century, including Albrecht Dürer, Lucas Cranach, Théodore Géricault, and Francisco de Goya, among many others, are featured inThe Plains of Mars: European War Prints, 1500-1825. On loan from the Sarah Campbell Blaffer Foundation at the Museum of Fine Arts, Houston, the works of art included in this exhibition examine the topics of war and peace, propaganda, heroism, brutal conflicts, and the harrowing aftermath of battle. Spanning from the Renaissance to the Romantic periods and encompassing a wide geographic scope including Italy, Germany, France, Spain, the Low Countries, England, and North America, the prints depict triumphant Renaissance soldiers, devastating scenes of violence, and satirical caricatures of political figures. Also on display is Goya’s compelling “Disasters of War” series, completed in response to the brutality of the Spanish War of Independence. Goya’s prints serve as a powerful testament to the horrors faced by both soldiers and civilians. Under the direction of Professor Felicia Else and Shannon Egan, Melissa Casale ‘19 and Bailey Harper ‘19 have researched and written didactic labels, catalogue essays, and created an interactive digital interface to complement the exhibition. Together, Melissa and Bailey will lead public tours of the exhibition. A Gallery Talk by Prof. Peter Carmichael will draw connections between the depictions of warfare on view in the Gallery with representations of the American Civil War. James Clifton, Director of the Sarah Campbell Blaffer Foundation at the Museum of Fine Arts, Houston, will be delivering a lecture in conjunction with the exhibition. Dr. Clifton, who also serves as curator of Renaissance and Baroque painting at MFAH, curated the exhibition in its first iteration and wrote the exhibition catalogue (published by Yale University Press). Dr. Clifton’s lecture not only will provide an overview of the exhibition, but also will focus on the concept of “mediated war.” A full-color catalogue with images and essays by Bailey Harper ’19 and Melissa Casale ’19, under the supervision of Profs. Felicia Else and Shannon Egan, is planned to accompany the exhibition.https://cupola.gettysburg.edu/artcatalogs/1028/thumbnail.jp